首页
外语
计算机
考研
公务员
职业资格
财经
工程
司法
医学
专升本
自考
实用职业技能
登录
外语
Scientists say they have high hopes for a drug that could one day provide a new form of treatment for HIV-AIDS. A compound, whic
Scientists say they have high hopes for a drug that could one day provide a new form of treatment for HIV-AIDS. A compound, whic
admin
2010-08-21
41
问题
Scientists say they have high hopes for a drug that could one day provide a new form of treatment for HIV-AIDS. A compound, which interferes with an elusive protein used by the HIV virus to infect human cells, has worked extremely well in monkeys. If the drug proves effective in human trials, scientists say, it could bolster (加强) the effectiveness of two existing AIDS drugs, particularly in fighting drug-resistant strains of the virus.
Researchers at the pharmaceutical (制药的) company Merck are very excited about an experimental drug, which has worked as well in monkeys infected with a primate version of the virus as any of the existing, anti-AIDS drugs.
It works by blocking one of three proteins, or enzymes, the HIV virus uses to gain entrance into and infect human immune system cells.
Inhibitor drugs have been developed to block two of the proteins, to slow progression of the disease after infection. They have become standard therapy as a "cocktail" for people infected with HIV
Those enzymes are reverse transcriptase (转录酶) and protease (蛋白酶). The first converts the virus’ genetic material into that of its host cells. The second chops up the resulting larger proteins into smaller pieces, producing smaller viral particles that infect new cells.
The third prong of cellular attack is a protein called integrase (整合酶), which experts say has been harder to block. Once HIV fools host cells by changing its genetic information so it can enter them. integrase acts like a cut and paste operation in a word processor, deleting on immune cell’s genetic material and replacing it with its own.
An integrase inhibitor would give doctors a third line of attack against HIV infection, according to virologist Daria Hazuda of the division of Virus and Cell Biology at Merck.
"This would offer a third class of anti-retroviral medications that can be combined with reverse transcriptase inhibitors and pretense inhibitors. And since it is a new mechanism of action, these compounds are active against multi-drug resistant variants. So variants that are resistant to all current therapies have been selected in HIV-patients," she said.
Current anti-AIDS drugs eventually become resistant to therapy, or stop working, because the virus changes its shape.
While researchers are encouraged by the success with the compound’s effectiveness in monkey trials, developing a drug that is equally effective in humans can be difficult.
Steven Young is executive director of the Department of Medicinal Chemistry at Merck. He says, if scientists find a compound that is equally effective in people, the company would ask U.S. regulators to speed approval of the drug.
"Yeah, I really think that’s what we’re hoping for." he said. "I mean. we need to get data that show it has robust anti-viral effects in people. And if we’re able to get that data. I think we would petition for fast track status."
Dr. Young says an integrase inhibitor has the potential to prevent drug resistance.
"To ensure our best chances of preventing resistance, we would give this as part of a cocktail therapy," he added. "And I think it’s really our plan that we would test this with reverse transcriptase inhibitors and pretense inhibitors, as well."
if the drug proves effective in human trials, it could enhance the effectiveness of existing AIDS drugs in ______.
选项
答案
fighting drug-resistant strains of the virus
解析
根据题干中的关键词human trials和existing AIDS drugs定位到第一段最后一句,可知科学家表示,该药物如果在人体试验中被证明是有效的,就会增强现存两种治疗艾滋病药物的效力,特别是在对抗病毒抗药性方面的效力,由此可得答案。
转载请注明原文地址:https://jikaoti.com/ti/rAFMFFFM
0
大学英语六级
相关试题推荐
OnesummermywifeChrisandIwereinvitedbyfriendstorowdowntheColoradoRiverinaboat.Ourexpeditionincludedmanyhi
OnesummermywifeChrisandIwereinvitedbyfriendstorowdowntheColoradoRiverinaboat.Ourexpeditionincludedmanyhi
A、Theman’smother.B、Theytakehimwiththem.C、Thewoman’smotherD、Ababy-sitter.A本题问“谁将照顾Msx”。从文中很容易知道是"grandmother",下文男士又说
A、Theamountofskinaffectedbythecut.B、Thecauseofthecut.C、Theamountofbleeding.D、Thenumberofnerveendingsirrita
A、It’sarequirementforpsychologymajors.B、Shewasn’tabletogetintothetraditionalcourse.C、Shelivesfarfromtheunive
Untilthenineteensixties,blackpeopleinmanypartsoftheUnitedStatesdidnothavethesamecivilrightsaswhitepeople.
Untilthenineteensixties,blackpeopleinmanypartsoftheUnitedStatesdidnothavethesamecivilrightsaswhitepeople.
Junglecountryisnotfriendlytoman,butispossibletosurvivethere.Youmusthavetherightequipmentandyoumustknowa
A、Stayandnegotiateormove.B、MoveclosertotheUniversityornearthesubway.C、Fightforasmallincreaseoracceptsanin
A、Maryignoredherparents’advice.B、Marywentswimmingintherain.C、Marytookherparents’advice.D、Marywasagoodswimmer
随机试题
用外人的眼光来看,微软公司似乎是在以闪电般的速度发展着。然而,从内部来看,对发展太缓慢的指责与日俱增。微软公司有3000名员工,生产180多种不同的产品,至少有5个管理层。公司的员工开始抱怨文案主义和决策迟缓的问题。日益明显的官僚化倾向甚至使公司失去了几个
立方体抗压强度的含义包括()。
水泥混凝土面层施工应严格控制水灰比,最大水灰比不应大于( )。
融资租入的固定资产,因所有权不属于企业,所以不计提折旧。()
得出学习即强化的观点的实验是()。
以下关于宏操作QuitAccess的叙述中,正确的是()。
请在“考试项目”菜单上选择“字处理软件使用”菜单项,完成以下内容。1.在指定文件夹下打开文档WTl2.DOC,其内容如下。[文档开始]美国的信息工业信息技术及信息工业动摇了传统商业交易的基础,改变了人们的消费方式,相继问世的
Afeelingoftirednessalmost______thesoldierondutyandhehadtostrugglehardtokeepawake.
Whatdoyoudoondayswhentheairdoesn’tsmellright?Soon,youmightjustcheckGoogleMaps.GooglehasteamedupwithS
A、Theplayersusearoundballinthegame.B、Theplayerscannotpasstheballwiththeirhands.C、Thegameisarugbygame.D、T
最新回复
(
0
)