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  3. The Embarrassing Pharmaceutical Industry The image of drug industry The drug industry’s image problems are beginning to hurt

The Embarrassing Pharmaceutical Industry The image of drug industry The drug industry’s image problems are beginning to hurt

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问题                             The Embarrassing Pharmaceutical Industry
The image of drug industry
    The drug industry’s image problems are beginning to hurt pharmaceutical companies where it matters most-- at the bottom line.
    A year after Merck’s withdrawal of its arthritis medicine Vioxx led to an industry wide credibility crisis, the Food and Drug Administration is blocking new medicines that might previously have passed muster. Doctors are writing fewer prescriptions for antidepressants and other drugs whose safety has been challenged, like hormone replacement therapies for women in menopause.
    Meanwhile, insurers and some states are taking advantage of the backlash against the industry to try shifting patients to older, generic drugs, arguing that they work as well as newer and more expensive branded medicines. Overall, prescriptions continue to rise slightly, but an increasing share of prescriptions are going to generic drugs. Also, consumers seem to be less responsive to aggressive drug marketing.
The industry lost trust
    "A lot of the demand that the industry has created over the years has been through promotion, and for that promotion to be effective, there has to be trust," said Richard Evans, an analyst covering drug stocks at Sanford C. Bernstein and Company. "That trust has been lost."
    In the background, new competitors are forcing the old-line drug giants to struggle to keep pace. Biotechnology companies like Genentech are taking the lead in finding new treatments for cancer, a promising and lucrative field.
    Executives of the major drug companies say they expect public scrutiny in the wake of problems with Vioxx and other drugs. But they say they are concerned that consumer mistrust has led to unrealistic expectations about drug safety and risks, stunting the development of new medicines.
    "I think there is an overall unreasonable expectation right now that there is such a thing as a risk free drug," said Sidney Taurel, chief executive of Eli Lilly & Company.
    The major drug makers remain highly profitable. But at some, including Pfizer and Merck, the largest and third-largest American companies in terms of revenue, sales are stagnant and profits are failing, leading to layoffs and-- for the first time in years-- cuts in research budgets. The drug industry, which is dominated by companies based in this country, is hardly in a full-blown crisis, and layoffs are occurring mainly on the margins of its work force. Pfizer alone will make about ＄ 8 billion in profit this year, on sales of about ＄ 51 billion, and invest more than ＄ 7 billion in research and development although the company’s research spending fell 6 percent in the third quarter of 2005 compared with the same period in 2004, and Pfizer expects it to stay flat or decline in the coming years. Overall, the industry spends more than ＄ 30 billion annually on research and development.
    But for the companies, and for patients who are counting on industry research to produce new treatments for diseases like rheumatoid arthritis and diabetes, these are trying times. Wall Street has also taken notice of the industry’s woes. Shares of Pfizer are near their lowest levels since 1997, closing Friday at ＄ 22.43, and a broad index of drug stocks has fallen 25 percent in five years. In contrast, shares of biotechnology companies are soaring.
    Without new drugs to promote as patents expire, and with the bar set so high by the blockbusters of the last decade, the old-line companies have depended on stopgap measures to protect sales, like reformulating existing drugs so they can be taken once a week instead of once daily. At the same time, they have used consumer advertising to drive patient demand. But those strategies appear to be losing their effectiveness, as consumers become more skeptical and insurers rebel against high prices for drugs that are not therapeutic breakthroughs.
Public opinions on drug price and quality
    "Is the public more cynical? Yes," said Dr. John LaMattina, Pfizer’s president of global research. "There’s a perception that we don’t bring much to the party."
    Consumers have been irritated for years by drug prices in the United States, which are higher than in other industrialized countries. But anger at the industry reached a new pitch in the summer of 2004, with the disclosure that several companies had suppressed the results of clinical trials that showed an increased risk of suicidal thoughts by people taking antidepressants.
    Then Merck stopped selling Vioxx after a clinical trial showed that the painkiller increased the risk of heart attacks and strokes. Internal Merck documents showed that company executives and scientists were concerned about Vioxx as early as 1997 but rejected plans to conduct a study of the heart risks. Merck has said it acted properly in its handling of Vioxx studies.
    A poll last month showed that only 9 percent of Americans believed drug companies were generally honest, down from 14 percent in 2004. In contrast, 34 percent of people said they trusted banks, and 39 percent trusted supermarkets.
    "We’ve created an impression with the American public that when a drug is approved, it’s perfectly safe," said Billy Tauzin, president of the Pharmaceutical Research and Manufacturers of America, a lobbying organization for brand-name drug companies. "We have not done a good job about educating the patients of America that all drugs come with significant side effects."
    Mr. Tauzin said the industry was "beginning to make progress and turn. things around." He said it was addressing its image crisis by being more careful with its advertising, by pledging more disclosure of clinical trial results and by working to make low-priced drugs available to poor and uninsured Americans.
    The industry is counting on research into genetics and the basic mechanisms of cellular behavior to produce genuine breakthroughs in treatment for diseases like diabetes. But executives and outside analysts warn that such a revival will probably not happen before the end of this decade at the earliest.
    "Early stage pipelines are very, very full in a lot of companies," said Mr. Taurel of Lilly, which is the sixth-largest American drug company, and one of the few that is substantially increasing research spending. "But it will take some time for all of these products to reach the marketplace."
    Further, the companies are victims of their own success in some important drug categories, such as diabetes, where existing treatments work well enough to discourage the F. D. A. from approving new drugs if they have significant side effects.
The unsatisfactory new drugs
    Last month, Bristol-Myers Squibb said it might stop research on Pargluva, a new diabetes drug, because the F.D.A. had said it would not approve it without additional clinical trials that might take up to five years.
    Pargluva is not the only drug the federal regulatory agency has blocked recently. In September, the agency turned down two drugs from Pfizer, a painkiller and an osteoporosis(骨质疏松症) medicine. Last month, it rejected Johnson ＆ Johnson’s bid to market a drug to treat premature ejaculation.
    Before the Vioxx withdrawal, the F.D. A. would probably have approved Pargluva, and the other drugs would have had a better chance, said Les Funtleyder, an analyst with Miller Tabak. Now the agency is taking longer to review drugs and weighing side effects more seriously, he said.
    "The F. D. A. has changed," Mr. Funtleyder said. "Nobody wants to be on ’60 Minutes’ being asked about why a dangerous drug was approved," he added.
Consumers have been irritated for years by ______.
选项
答案drug price and drug quality
解析 文章第三段“Meanwhile，insurers and some states are taking advantage of the backlash against the industry to try shifting patients to older，generic drugs，arguing that they work as well as newer and more expensive branded medicines.”
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