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  3. American this year will swallow 15, 000 tons drugs of aspirin, one of safest and most effective invented by man.

American this year will swallow 15, 000 tons drugs of aspirin, one of safest and most effective invented by man.

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问题    American this year will swallow 15, 000 tons drugs of
aspirin, one of safest and most effective invented by man.                 【M1】 ______
The most popular medicines in the world today, it is an ef-                【M2】 ______
fective pain reliever. Its bad effects are relatively mild, and it
is cheap.
   For millions of people suffered from arthritis, it is the               【M3】 ______
only thing that works. Aspirin, in short, is truly the 20th -
century wonder drug. It is also the second largest suicide
drug and is the leading cause of poisoning between chil-                   【M4】 ______
dren. It has side effects that, if relatively mild, are largely            【M5】 ______
unrecognized among users.
   Although aspirin was first sold by a German company
in 1899, it has been around more longer than that. Hippocra-
tes, in ancient Greece, understood the medical value of the
leaves and tree bark which today are known to contain salic -              【M6】 ______
ylates(水杨酸盐), the chemical in aspirin. During the 19th
century,there was a great number of experimentation in Eu-                 【M7】 ______
rope with this chemical and it led in the introduction of aspi-
rin. By 1915, aspirin tablets were available in the United                 【M8】 ______
States.
   A small quantity of aspirin (two five - grain tablets)
relieves pain and inflammation. It also reduces down fever                 【M9】 ______
by interfering with some of the body’s reactions. Specifical-
ly, aspirin seems to slow down the formation of the acids in-
volved in pain and the complex chemical reactions that
cause fever. The chemistry of these acids is not fully under-
stood, and the slowing effect of aspirin is well known.                   【M10】 ______
【M1】
选项
答案在safest前加定冠词“the”
解析 后面有most effective，safest这个最高级的表达形式，因此前面必须加定冠词 the。
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