American this year will swallow 15, 000 tons drugs of aspirin, one of safest and most effective invented by man. 【M1】______

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问题     American this year will swallow 15, 000 tons drugs of
aspirin, one of safest and most effective invented by man.      【M1】______
The most popular medicines in the world today, it is an el-     【M2】______
feetive pain reliever. Its bad effects are relatively mild, and it
is cheap.
    For millions of people suffered from arthritis, it is the   【M3】______
only thing that works. Aspirin, in short, is truly the 20th -
century wonder drug. It is also the second largest suicide
drug and is the leading cause of poisoning between ehil-        【M4】______
dren. It has side effects that, if relatively mild, are largely 【M5】______
unrecognized among users.
    Although aspirin was first sold by a German company
in 1899, it has been around more longer than that. Hippocra-
tes, in ancient Greece, understood the medical value of the
leaves and tree bark which today are known to contain salic-    【M6】______
ylates (水杨酸盐), the chemical in aspirin. During the 19th
century, there was a great number of experimentation in Eu-     【M7】______
rope with this chemical and it led in the introduction of aspi-
rin. By 1915, aspirin tablets were available in the United      【M8】______
States.
    A small quantity of aspirin ( two five - grain tablets )
relieves pain and inflammation. It also reduces down fever      【M9】______
by interfering with some of the body’s reactions. Specifically,
aspirin seems to slow down the formation of the acids in-
volved in pain and the complex chemical reactions that
cause fever. The chemistry of these acids is not fully under-
stood, and the slowing effect of aspirin is well known.         【M10】______
【M1】

选项

答案在safest前加定冠词“the”

解析 后面有most effective,safest这个最高级的表达形式,因此前面必须加定冠词the。
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