When he was______, none of his friends gave him a helping hand.

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问题 When he was______, none of his friends gave him a helping hand.

选项 A、down and off
B、up and down
C、up and on
D、down and out

答案D

解析 句意:当他穷困潦倒之时,没有一个朋友伸出援助之手。down and out穷困潦倒,孤苦无助。down and off无此固定搭配。up and down上上下下。up and on来来回回。
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